Notes on...
Calculating the molecular weight
The molecular weight M of a peptide may be estimated by calculating
where Ni are the number, and Mi
the average residue molecular weights, of the amino acids. MN + MC are
added to the total in order to account for the termini: H at the N-terminus and OH at the C-terminus. Of course,
if the termini are modified, these additions are replaced by those of the modifiers.
The resulting molecular weight depends on what values the algorithm uses. Some of the values Innovagen's
Peptide Calculator uses are:
A, Ala | 71.07793 | C, Cys | 103.1454 | D, Asp | 115.0873 | E, Glu | 129.1139 |
F, Phe | 147.1734 | G, Gly | 57.05138 | H, His | 137.1394 | I, Ile | 113.1576 |
K, Lys | 128.1724 | L, Leu | 113.1576 | M, Met | 131.1985 | N, Asn | 114.1028 |
P, Pro | 97.11508 | Q, Gln | 128.1293 | R, Arg | 156.1861 | S, Ser | 87.07733 |
T, Thr | 101.1039 | V, Val | 99.13103 | W, Trp | 186.2095 | Y, Tyr | 163.1728 |
H | 1.00797 | OH | 17.00738 | phos-Ser | 167.0573 | ||
Acetyl | 43.04453 | Amide | 16.0228 | phos-Thr | 181.0838 | ||
Biotin | 227.3056 | phos-Tyr | 243.1528 |
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